PRF Technology

At TMJ & Sleep Therapy Centre of San Diego we utilize the Bio-PRF system. Bio-PRF is the first commercially available horizontal centrifuge specifically designed to produce platelet rich fibrin.

Bio-PRF is a 100% natural and autologous three-dimensional fibrin scaffold derived from peripheral blood. Following effective centrifugation, platelets and leukocytes are accumulated within the upper PRF layer. Protocols utilized using horizontal centrifugation with the Bio-PRF system can accumulate up to 4 times more platelets and leukocytes when compared to standard fixed-angle centrifuges.

  • 100% autologous
  • Improves Vascularization
  • Growth factors release > 10 days
  • No chemical additives

On a fixed-angle centrifuge, platelets, white blood cells and red blood cells accumulate on the back walls of tubes. This leads to improper cell separation and a reduction in platelet and leukocyte concentration.
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On a horizontal centrifuge, the cells separate much more efficiently throughout the entire tubes. This leads to better layer separation and favors cells that are evenly distributed throughout the PRF clot.

Advantages of Horizontal Centrifugation

  • Up to 4 times more platelets and leukocytes
  • Higher growth factor release when compared to fixed-angle centrifugation
  • Better horizontal layer separation between PRF-clot and red blood cells
  • More even distribution of regenerative cells throughout the PRF-clot
  • Less cell damage/death on the tube walls produced on fixed-angle centrifugation
  • Less RBCs accumulation

The latest heating technology to extend PRF resorption.
The Bio-Heat technology is an advancement and disruption in the industry to extend the resorption properties of PRF from 2-3 weeks to 4-6 months. This new development and protocol involve an additional heating process following centrifugation where the platelet poor plasma (PPP) layer is heated at specific temperatures to denature and reorganize albumin.

This drastically extends the working resorption properties of PRF. The Bio-Heat technology has been extensively utilized in various fields of medicine and dentistry, including facial aesthetics.By heating and denaturing albumin, a modification in the secondary structure after heating transforms liquid PRF into a tridimensional structure. The heating process consists of a pronounced modification in the surface structure of albumin within its resorption properties favoring more stability when implanted back into host tissues.

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